##submission.abstract##
Objectives: The objective of our study was to compare anthropometric and biochemical parameters in adolescents of one and both diabetic parents along with β cell function in both the groups.
Material and methods: It is an observational analytical study which had been carried out in the Department of Biochemistry, JNMC, DMIMS (DU), Sawangi (M), Wardha. In which 50 adolescents (17±2 years of age) participated. Out of them 42 were having one diabetic parent while 8 had both diabetic parents. All subjects were evaluated for WC, BMI, BP, FPG, Lipid profile, insulin level, insulin resistance and β-cell function by standard methods.
Observations and Result: Body Mass Index (BMI), serum triglyceride (TG) levels, serum insulin levels, insulin resistance and β-cell function was significantly high in adolescents of both diabetic parents as compared to one diabetic parent. These were 26.99 ± 6.67kg/m2, 102.04  ±  28.52 mg/dl, 22.7 ± 4.96 μIU/ml,  4.97 ± 1.37 and 211.74 ± 113.37 % respectively in adolescents of both diabetic parents as compared to 22.21 ± 3.94 kg/m2, 74.59 ± 27.73 mg/dl, 15.42 ± 6.85 μIU/ml, 3.50 ± 1.66 and  348.2 ± 105.8 % respectively in adolescents of one diabetic parent.
Conclusion: Insulin resistance syndrome (IRS) is a constant precursor for type-2 DM, which starts 10-20 years before the development of type-2 DM. So we can say that adolescents especially whose both parents are diabetic are on the edge of development of insulin resistant syndrome and later the Diabetes mellitus.