##submission.abstract##
Background: In periodontitis, the inflammatory cells synthesized and secreted
proinflammatory mediators, namely interleukin 1? and ?, and tumour necrosis factor
?, interleukin 6, prostaglandins. A great interest has been developed regarding the
systemic effect of these proinflammatory cytokines. Evidence suggests that they
cause a state of altered lipid metabolism, manifested as dyslipidemia, either of
heperlipidemia or hypolipidemia. Thus, a close association of periodontal disease
and systemic conditions related to dyslipidemia is suggested, though not established
yet.
Objectives: The present study was designed to evaluate the effects of nonsurgical
periodontal therapy on serum lipid levels in the subjects with moderate
to severe generalized chronic periodontitis by comparing the serum levels of total
cholesterol, triglyceride, LDL and HDL before and after
periodontal therapy.
Materials and Methods: The selected subjects (n= 40) were randomly divided
into two groups: Treatment group (treated with scaling and root planing +
systemic Doxycycline (200 mg first day orally followed by 100 mg daily for 14
days) and Control (received no treatment). The periodontal parameters
considered were gingival index, probing pocket depth and clinical attachment
level, while the metabolic parameters were serum triglyceride, cholesterol, LDL
cholesterol, HDL cholesterol (together called as serum lipid levels). The parameters
were recorded on day 0 and 90.
Results: Serum triglyceride, serum cholesterol and LDL cholesterol levels were
reduced with significant improvement in gingival health, pocket depth and clinical
attachment level after periodontal therapy.
Conclusion: Periodontal therapy is effective in reducing the serum lipid levels,
thereby reduces the risk of associated systemic diseases.
Key words: Cytokines, Periodontitis, Serum Cholesterol, Triglycerid,
Prostaglandin, Pocket Depth, Clinical Attachment Level