PROTECTIVE EFFECTS OF SOLANUM LYCOPERSICUM FRUIT EXTRACT ON CYCLOPHOSPHAMIDE INDUCED MICRONUCLEI IN BONE MARROW CELLS OF MICE.

K. Rudrama devi Sri Vani, Minny Jael .P

Abstract


In the present investigations the antimutagenic effect of solanum lycopersicum fruit extract has been evaluated against cyclophosphamide (CP) induced micronuclei in bone marrow cells of mice. Single i.p administration of solanum lycopersicum fruit extract at various test doses namely 250, 500 and 1000 mg/kg b.w have given protection when 24hr prior administration of single doses of cyclophosphamide (50mg/kg b.w). A dose dependent inhibition of micronuclei was observed when animals were primed with solanum lycopersicum fruit extract. Thus the results indicate preventive effects of solanum lycopersicum fruit extract against cyclophosphamide induced genotoxicity in bone marrow cells of mice. Therefore the data showed SL fruit extract is a safer dietary component in cancer chemo preventive strategy.


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