##submission.abstract##
Ariamycin (Doxorubin) is a potent antitumor agent used worldwide for the treatment of many cancers. It has been demonstrated to have a potential for initiating genetic events in non tumor cells in human and in animal models. Due to the importance of adriamycin in chemotherapy for the treatment of cancer, it is important to reduce its toxicity in normal cells. This objective can be achieved by concurrent administration of free radical scavenging agent such as antioxidants Phythanthus emblica fruit extract was used to evaluate its ability to reduce the induction of genetic damage (MNPCEs) by anticancer drug in bone marrow cells of male mice. Two experiments wee conducted. In the first experiment the animals were fed with 100, 250 and 500 mg/kg of PFE for two weeks to analyse the antimutagenicity of fruit extract on micronuclei incidence. In the second experiment Group I were given only saline, G – II animals were administred with single dose of 16 mg/kg adriamycin and G – III the animals were fed with 500 mg/kg PFE for two weeks G – IV were administered with 500 mg/kg for two weeks and adriamycin 16 mg/kg as single dose, one day before the last treatment. Results indicated that the treatment with PFE, co-concurrent administration with adriamycin reduced in the percentage of MNPCEs. No significant difference was observed with treated group of animals. Treatment of mice with PFE did not induce any significant variation in the incidence of MNPCEs as compared to control values. Therefore it is concluded that PFE may act as positive modulators of cytotoxic anticancer agents.