Formulation and Evaluation of Orodispersible Antacid Tablet For Geriatric Patient

Authors

  • Gopal S. Gandh*,

Abstract

Orodispersible tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. In geriatric patient acidity are commonly occurring due to decrease metabolic and weak hepatic function. In the present study orodispersible tablets of an antacid aluminium hydroxide was prepared by direct compression method using crosspovidone, Crosscarmellose and Indion 414, as superdisintegrants. The tablets prepared were evaluated for various parameters like hardness, friability, disintegration time, wetting time and acid neutralizing capacity. All the parameters were found to be within limits. The developed formulation of antacid showed good palatability and dispersed within 40 seconds. When the results were compared with that of chewable tablets or dispersible tablets was found to be better with respect to simple manufacturing and acid neutralizing capacity.

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Published

2013-10-16

Issue

Vol. 1 No. 1 (2011): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

Section

Articles

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“I ……………………………………….certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.”
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