Anhydrous ferrous sulphate as an efficient and eco-friendly catalyst for the One-pot multicomponent synthesis of β-acetamido ketones under mild and heterogeneous conditions and their microbial study

Authors

  • Dinanath Deoram patil PUNE UNIVERSITY

Abstract

Abstract: A variety of _-acetamido ketones and ketoesters are readily prepared in high yields under extremelymild conditions via a three component coupling of aromatic aldehydes, enolizable ketones or _-ketoesters andnitriles in the presence of 10 mol% of ferrous sulphate  and a stoichiometric amount of acetylchloride. A solution of 10 mol% of ferrous sulphate  in acetonitrile provides a convenient reaction medium to carry out athree component reaction under mild conditions with high yield .Synthesized compounds are studied for their microbial activity.

References

Published

2014-01-11

Issue

Vol. 3 No. 12 (2013): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPININION

Section

Articles

License

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