Effect of Lutein in Development of Experimental Diabetic Nephropathy in Rats

Authors

  • Taruna Katyal, Gurpreet singh R.D. Budhiraja

Abstract

The present study has been designed to investigate the effect of lutein in streptzotocin  induced diabetic nephropathy in wistar rats. Diabetic nephropathy was induced by administering single dose of streptozotocin in wistar rats. DN was clinically assessed by the estimation of various biochemical parameters and histopathological studies of renal tissue. Diabetic nephropathy was assessed biochemically by blood urea nitrogen, serum creatinine, total urinary protein. Oxidative stress assessed by measuring the TBARS level &renal reduced glutathione levels. Treatment with high dose of lutein (1.5mg/kg, p.o.) shows significant improvement in (BUN, serum creatinine, total urine protein, ratio of kidney wt/body wt, TBARS, reduced glutathione) renal parameters studied for DN. It may be therefore concluded that renoprotective effect of lutein is due to its antioxidant property. Lutein may prevent overproduction of ROS and to increase the removal of preformed ROS This may prove to be effective in preventing the development and progression of diabetic nephropathy.

References

Published

2014-01-11

Issue

Vol. 3 No. 12 (2013): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPININION

Section

Articles

License

“I ……………………………………….certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.”
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