Pharmacological Assessment of Polygonum flaccidum M.

Authors

  • Bijoy Karon Md. Ahad Ali Khan, Md. Abdur Noor, Md. Torequl Islam*

Abstract

Plants are rich source of pharmacologically active agents, which could be exploited in human disease management. Polygonum flaccidum M. is used by the Kabiraj (traditional practitioners) in pain and gastrointestinal motility. The present study was conducted to evaluate some pharmacological activities of the ethanol (EEPF), methanol (MEPF) and petroleum ether (PEPF) extractives of P. flaccidum. The 500 mg/kg of EEPF reduced the diarrhoeal faeces 8.2 and extends the latency period 1.38 h in the castor oil induced diarrhoeal mice. Similarly, the same dose of EEPF extends the charcoal defecation by 6.05 h in comparison to the standard loperamide. The MEPF produced a reduction of the onset (22.6 min) and duration (28.8 min) of pentobarbitone-induced hypnosis tests. All the extractives exhibited dose dependent activity

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Published

2014-02-16

Issue

Vol. 1 No. 1 (2011): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

Section

Articles

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“I ……………………………………….certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.”
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