EVALUATION OF ANTIFERTILITY POTENTIAL OF CALOTROPIS GIGANTEA LINN. IN FEMALE ALBINO RATS.

Authors

  • M. Mishra, R. K Gautam, R. Mathur*

Abstract

The present study has been undertaken to evaluate antifertility and ovaro-uterotoxic activities of the extracts of Calotropis gigantea Linn. Animals studied were divided into various groups control and experimental groups. Crude and ethanolic extracts were prepared and 150 and 300 mg/kg body weight doses were selected. Oestrogenicity/antioestrogenicity was tested by using bilaterally ovariectomized immature rats. Biochemical parameters viz. uterine glycogen, total protein, acid and alkaline phosphatase were measured and compared with control and vehicle. The findings suggest that the extracts are strong antiestrogenic and antiprogestagenic. Sharp decline was found in uterine glycogen, total proteins and acid phosphatase level whereas the level of alkaline phosphatase was found to increase. Though the extracts are highly toxic at higher doses yet they exhibit potential to be elucidated as female antifertility agents with proper control of toxicity.

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Published

2014-02-23

Issue

Vol. 1 No. 3 (2011): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

Section

Articles

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“I ……………………………………….certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.”
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