PHYTOTHERAPEUTIC APPROACH AGAINST ALUMINIUM INDUCED BIOCHEMICAL CHANGES IN ALBINO MICE

Abstract

In the modern life the exposure of Aluminium is inevitable as it is released primarily from natural process and anthropogenic sources. It is the third most abundant element in nature accounting for nearly 8% of the Earth’s crust.Humans are exposed to Al by packaging, medicines, water and air. Daily intake of Al from food ranges from 2.5 -13 mg/day. Despite of its low persistence it exhibits toxicity to humans. Drinking water also contributes around 0.4mg /day. The present study is aimed for amelioration in treatment of aluminium induced toxicity by phytotherapy. Swiss albino mice weighing (25±5g) were taken and randomly divided into five groups. Al is xenobiotic that induces free radical mediated toxicity and reproductive toxicity and interferes with a number of body functions such as CNS, Liver, and Kidney. Hb% and RBC decreased remarkably while WBC count increased due to Al, thereby indicating altered metabolism. Al showed significant rise in serum transaminases, creatinine, blood urea and lipid peroxidation in brain. The decreased activity of brain marker Acetylcholinestrase (AchE) is direct indication of oxidative damage resulting in free radical generation. Treatment with therapeutic agents (Triphala and garlic) caused reversal of the biochemical parameters thereby recouping the variables towards normal levels. Significant recoupment in the blood biochemical and tissue biochemical parameters was observed with Allium sativum per se and in combination with Triphala.