EFFECT OF PIOGLITAZONE AND IRBESARTAN ON HEMODYNAMIC AND METABOLIC PARAMETERS IN FRUCTOSE INDUCED DIABETES AS WELL AS HYPERTENSIVE RATS

Authors

  • K.G. Kanase*

Abstract

Combination of Pioglitazone (AT1 blocker) and Irbesartan (PPAR-γ agonist) is the most drug therapy used in diabetes hypertension. The aim of this study is to the effects of Irbesartan and pioglitazone alone and in combination, in the fructose overloaded rat, a model of diabetes hypertension. Fructose feeding caused significant elevations in blood pressure, blood glucose and the concentrations of plasma triglycerides and free fatty acids. High-density lipoprotein cholesterol (HDL-C) was significantly reduced and very low-density lipoprotein cholesterol (VLDL-C) was significantly elevated. All six week treatments groups reduced blood pressure, blood glucose triglyceridemia, total cholesterol and increased level of HDL and VLDL clearance. In conclusion, combination therapy significantly produced additive effect rather than single drug on hemodynamic and metabolic changes.

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Published

2014-02-23

Issue

Vol. 1 No. 6 (2011): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

Section

Articles

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“I ……………………………………….certify that I have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. I believe the manuscript represents valid work. I have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore I attest that I shall produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.”
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