EVALUATION OF ANTI-ULCER ACTIVITY OF VILLORITA CYPRINOIDES EXTRACT (BLACK WATER CLAMS) AGAINST IMMOBILIZATION STRESS INDUCED ULCER IN ALBINO RATS

Authors

  • Ajithkumar P*

Abstract

Villorita cyprinoides is a black water clam that belongs to a group of the genus Villorita; species cyprinoides (Fam:Corbiculidae) were found in the backwaters of Kerala, mainly in Vembanad backwaters. Clams are considered to be nutritious and delicious and are fished in considerable quantities in some coastal places, known to scavenge and deactivate free radicals both in vitro and in vivo. Clams were used traditionally to treat dyspepsia, piles, general debility and some skin and lung diseases. The present study was undertaken to evaluate the anti-ulcer activity of in Villorita cyprinoides extract (Black water clams) against immobilization stress induced ulcer models in Wistar rats. The extract (100 mg/kg & 200 mg/kg) showed significant (P<0.001) reduction in gastric volume, free acidity and ulcer index as compared to control. The present study revealed that Villorita cyprinoides extract (VCE) has potential anti ulcer activity in stress induced ulcer models. These results may further suggest that Villorita cyprinoides extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity by its antioxidant mechanism.

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Published

2014-02-23

Issue

Vol. 2 No. 6 (2012): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

Section

Articles

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