PRELIMINARY PHYTO-CHEMICAL INVESTIGATIONS OF METHANOLIC ROOTS EXTRACT OF CLERODENDRUM SERRATUM: ANTIULCER ACTIVITY AND HISTOPATHOLOGICAL STUDY OF STOMACH MUCOSA OF WISTAR RATS IN ETHANOL INDUCED ULCER

Authors

  • Anil Gupta

Abstract

Different parts of plant contain different constituents, which vary in activity, concentration or purity.  The therapeutic potential of Clerodendrum serratum especially antiulcer activity is documented in traditional books and literature. As till date there is no scientific data on antiulcer activity of roots of Clerodendrum serratum. Therefore, the present research work is aimed at evaluating antiulcer potential of the plant data and establish scientific basis for the same. Successive extraction was carried out on the roots of Clerodendrum serratum. Percentage yield of successive extraction were found as 1.65 and 44.27 for petroleum ether and methanol solvent respectively. The phytoconstituents were identified by chemical tests, which showed the presence of various phytoconstituents (carbohydrate, tannin, terpenoid) in methanolic roots extract of Clerodendrum serratum. In ethanol induced model methanolic root extract of Clerodendrum serratum at a dose of (200 mg/kg, p.o) has produced signiï¬cant inhibition of ulcerative lesion by 53.2% as compared to the control group. Rabeprazole significantly decreased number of ulcer, ulcer score and ulcer index as compared to the control value. It showed also significant (p≤0.01) decrease in number of ulcers, ulcer score and ulcer index in ethanol induced ulcer. Ethanol produced reactive species which are responsible for mucosal injury and lipid peroxidation, a free radical mediated process that ultimately destroys lipid membrane. The methanol extract of Clerodendrum serratum roots possess significant antiulcer property in a dose dependent manner by improving gastric mucosal defense mechanism.

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Published

2014-10-07

Issue

Vol. 1 No. 7 (2011): JOURNAL OF PHARMACEUTICAL RESEARCH AND OPINION

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Articles

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